When pressure on capillaries is unrelieved, the endothelial cells lining those capillaries become disrupted with platelet aggregation forming microthrombi.

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Continuous pressure on tissue between the bony prominence and a resistant outside surface distorts capillaries and occludes the blood flow and oxygen supply. If the pressure continues unrelieved, the endothelial cells lining the capillaries become disrupted with platelet aggregation, forming microthrombi that block blood flow and cause anoxic necrosis of surrounding tissues.

When Pressure on Capillaries Is Unrelieved, the Endothelial Cells Lining