The sickle cell trait differs from sickle cell disease in that the child with sickle cell trait:
A)inherited normal hemoglobin A from one parent and Hb S from the other parent, whereas the child with sickle cell disease has Hb S from both parents.
B)has a mild form of sickle cell disease that causes sickling during fever and infection, but not during acidosis or hypoxia, whereas the child with sickle cells disease develops sickling during each of these conditions.
C)has a milder form of the disease that is characterized by vaso-occlusive crises and is believed to result from higher hemoglobin values and viscosity.
D)has the mildest form of the disease with normal hemoglobin and hemoglobin F, which prevents sickling.

Question

Quizplus · Accepted Answer

Sickle cell-thalassemia disease and sickle cell-Hb C disease are heterozygous forms in which the child simultaneously inherits another type of abnormal hemoglobin from one parent. Sickle cell trait, in which the child inherits Hb S from one parent and normal Hb A from the other, is a heterozygous carrier state that rarely has clinical manifestations (Table 28-3).

The Sickle Cell Trait Differs from Sickle Cell Disease in That