During an IgE-mediated hypersensitivity reaction, the degranulation of mast cells is a result of the action of _____ receptors. A)histamine bound to H₂ B)chemotactic factor of anaphylaxis bound to C)epinephrine bound to mast cell D)acetylcholine bound to mast cell

Question

Quizplus · Accepted Answer

If further exposure of a sensitized individual to the antigen occurs, one molecule of antigen may bind simultaneously to two molecules of IgE-Fc receptor complexes on the mast cell's surface (cross-link) resulting in activation of intracellular signaling pathways and mast cell degranulation . The antigen that triggers cross-linking must have at least two antigenic determinants on the same molecule. The most potent mediator is histamine, which affects several key target cells.

During an IgE-Mediated Hypersensitivity Reaction, the Degranulation of Mast Cells