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Immunodeficiencies may be genetic in origin. Two examples of these are Bruton's agammaglobulinemia, an X-linked disorder, and DiGeorge syndrome, caused by a deletion from chromosome 22. Bruton's results in underdeveloped B cells, while DiGeorge syndrome results in a missing or seriously underdeveloped thymus.
-In the human disease known as lupus, there is an immune reaction against a patient's own DNA from broken or dying cells. This kind of response typifies which kind of irregularity?
A) allergy
B) immunodeficiency
C) autoimmune disease
D) antigenic variation
E) cancer
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