What accounts for antibody switching (i.e., the switch of one B cell from producing one class of antibody to another antibody class that is responsive to the same antigen)?
A)mutation in the genes of that B cell, induced by exposure to the antigen
B)the rearrangement of V region genes in that clone of responsive B cells
C)a switch in the kind of antigen-presenting cell that is involved in the immune response
D)a patient's reaction to the first kind of antibody made by the plasma cells
E)the shuffling of exons for one C region type to another attached to the V-J transcript

Question

Quizplus · Accepted Answer

Antibody switching, also known as class switching, involves the shuffling of exons for one C region type to another attached to the V-J transcript. This process occurs during B cell maturation and is driven by cytokines produced by T helper cells. It allows for B cells to produce different classes of antibodies (e.g., IgM, IgG, IgE) that have different effector functions, while still recognizing the same antigen.

What Accounts for Antibody Switching (I