The Hox Genes Came to Regulate Each of the Following

The Hox genes came to regulate each of the following in what sequence, from earliest to most recent?
1) identity and position of paired appendages in protostome embryos
2) formation of water channels in sponges
3) anterior-posterior orientation of segments in protostome embryos
4) positioning of tentacles in cnidarians
5) anterior-posterior orientation in vertebrate embryos

A) 4 → 1 → 3 → 2 → 5
B) 4 → 2 → 3 → 1 → 5
C) 4 → 2 → 5 → 3 → 1
D) 2 → 4 → 5 → 3 → 1
E) 2 → 4 → 3 → 1 → 5