Use the following scenario for the following questions.
A few decades ago, Knudsen and colleagues proposed a theory that, for a normal cell to become a cancer cell, a minimum of two genetic changes had to occur in that cell. Knudsen was studying retinoblastoma, a childhood cancer of the eye.
-If there are two children born from the same parents, and child one inherits a predisposition to retinoblastoma (one of the mutations)and child two does not, but both children develop the retinoblastoma, which of the following would you expect?
A)an earlier age of onset in child one
B)a history of exposure to mutagens in child one but not in child two
C)a more severe cancer in child one
D)increased levels of apoptosis in both children
E)decreased levels of DNA repair in child one

Question

Quizplus · Accepted Answer

Child one inherited a predisposition to retinoblastoma, which means they already have one of the necessary genetic changes for cancer development. Therefore, they would likely have an earlier age of onset compared to child two who did not inherit this predisposition.

Use the Following Scenario for the Following Questions