If a plot of enzyme activity versus pH is sigmoidal then acid-base catalysis can be ruled out as a mode of catalysis.

Question

Quizplus · Accepted Answer

A sigmoidal plot of enzyme activity versus pH is not necessarily indicative of ruling out acid-base catalysis as a mode of catalysis. In fact, acid-base catalysis can still occur even in a sigmoidal plot, as it is dependent on the specific enzyme and substrate involved.

If a Plot of Enzyme Activity Versus PH Is Sigmoidal