Which statement is true about disulfide bonds and protein folding?
A)Disulfide bonds have no influence on protein folding since they only form after the protein adopts its native conformation.
B)Proteins occasionally adopt nonnative conformations and form improper disulfide bonds that can be reversed by the enzyme protein disulfide isomerase.
C)The folding of the native conformation is influenced more strongly by the formation of disulfide bonds than by the primary structure of a protein.
D)If a protein forms an improper disulfide bond it is irreversibly inactivated and must be targeted by the cell for degradation.

Question

Quizplus · Accepted Answer

Disulfide bonds can form during protein folding and stabilize the native conformation. However, if a protein adopts a non-native conformation, it may form improper disulfide bonds that can be corrected by the enzyme protein disulfide isomerase. Therefore, option B is correct. Options A and C are incorrect because disulfide bonds do influence protein folding and the primary structure of a protein is also important for determining the native conformation. Option D is incorrect because some improper disulfide bonds can be corrected and do not necessarily lead to irreversible inactivation of the protein.

Which Statement Is True About Disulfide Bonds and Protein Folding