Tetrodotoxin blocks voltage-gated sodium channels and ouabain blocks sodium-potassium pumps.If you added both tetrodotoxin and ouabain to a solution containing neural tissue,what responses would you expect?
A)immediate loss of resting potential
B)immediate loss of action potential with gradual loss of resting potential
C)slow decrease of resting potential and action potential amplitudes
D)no effect;the substances counteract each other

Question

Quizplus · Accepted Answer

Tetrodotoxin will block voltage-gated sodium channels, leading to an immediate loss of action potential. Ouabain will block sodium-potassium pumps, slowly decreasing the resting potential and action potential amplitudes over time. Therefore, adding both tetrodotoxin and ouabain to neural tissue solution would result in an immediate loss of action potential with gradual loss of resting potential.

Tetrodotoxin Blocks Voltage-Gated Sodium Channels and Ouabain Blocks Sodium-Potassium Pumps