Immune responses to idiotypes located outside the complementarity-determining regions (CDRs) result in:
A) Increases in autoantibody production
B) Downregulation of autoreactive B cells
C) Increases in activated regulatory T cells
D) Downregulation of MHC class II molecules on APCs

Question

Quizplus · Accepted Answer

Response to idiotypes located outside the CDRs leads to the formation of immune complexes. Interactions between the immune complexes and Fc receptors on B cells activate immuno-receptor tyrosine-based inhibitory motif (ITIM) signaling that results in inhibition of autoreactive B cells.

Immune Responses to Idiotypes Located Outside the Complementarity-Determining Regions (CDRs)