Which of the Following Is NOT a General Principle of the Chemical

Which of the following is NOT a general principle of the chemical mediators of
Inflammation?

A) Mediators originate either from plasma or from cells
B) The production of active mediators is triggered by microbial products or by host proteins
C) Most mediators perform their biologic activity by initially binding to specific receptors on target cells
D) One mediator can stimulate the release of other mediators by target cells themselves
E) Mediators can act on one or few target cell types
F) Once activated and released from the cell, most of these mediators last a long
Time (long-lived)
G) Most mediators have the potential to cause harmful effects