Endocannabinoids contribute to retrograde signaling in the hippocampus by A) blocking the reuptake transporters. B) blocking CB₁ autoreceptors on the presynaptic terminals. C) inhibiting Ca²⁺-mediated GABA release. D) activating the CB₁ receptors and increasing GABA release.

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Quizplus · Accepted Answer

Endocannabinoids contribute to retrograde signaling in the hippocampus primarily by inhibiting calcium-mediated GABA release. They are released from postsynaptic neurons and travel back to the presynaptic neuron, where they inhibit the release of neurotransmitters such as GABA by reducing calcium influx.

Endocannabinoids Contribute to Retrograde Signaling in the Hippocampus by