Which of the following do the original phorbol esters mimic?
A)hormones by binding and activating PKA,which potentiates the effects of Ca²⁺
B)DAG by binding and activating PKA,which potentiates the effects of carcinogens
C)cAMP by binding and activating PKA,which potentiates the effects of glucagon
D)PIP2 by binding and activating PKC,which potentiates the effects of Ca²⁺

Question

Quizplus · Accepted Answer

Phorbol esters mimic diacylglycerol (DAG) by binding and activating protein kinase C (PKC), not PKA as mentioned in the options, which plays a role in the signaling pathways that lead to various cellular responses, including those related to carcinogenesis. The correct mechanism involves PKC, not PKA, and the effects on carcinogens, not Ca²⁺ or glucagon. However, given the choices provided and focusing on the closest correct mimic (DAG), option B is selected despite the inaccuracies in the description.

Which of the Following Do the Original Phorbol Esters Mimic