Lithium salts have been used for years for the treatment of manic depression.Which of the following describes the mechanism of action for Li⁺?
A)It alters the conformation of a number of plasma protein receptors.
B)It increases the GTPase activity of G proteins.
C)It inhibits a number of enzymes in phosphoinositide metabolism.
D)It inhibits Ca²⁺ release from cytoplasmic organelles.

Question

Quizplus · Accepted Answer

Lithium ions inhibit several enzymes involved in phosphoinositide metabolism, including inositol monophosphatase and glycogen synthase kinase-3. This leads to a decrease in phosphatidylinositol signaling and likely contributes to its mood-stabilizing effects.

Lithium Salts Have Been Used for Years for the Treatment