What enzymatic step is NOT involved in the synthesis of mevalonate from acetyl-CoA?
A)formation of 3-hydroxy-3-methylglutaryl-CoA
B)b-ketothiolase-catalyzed condensation
C)formation of acetyl-CoA
D)HMG-COA reductase activity

Question

Quizplus · Accepted Answer

Formation of acetyl-CoA is not involved in the synthesis of mevalonate from acetyl-CoA. Acetyl-CoA is the starting point for the pathway and does not need to be synthesized. A is incorrect because the formation of 3-hydroxy-3-methylglutaryl-CoA is the first step in the pathway. B and D are incorrect because they are both enzymatic steps involved in the pathway.

What Enzymatic Step Is NOT Involved in the Synthesis of Mevalonate