Type 1 diabetes is highly associated with the inheritance of specific alleles of genes in the MHC cluster as well as other unrelated loci. Which of the following polymorphic alleles is most highly associated with the potential for the development of Type 1 diabetes?
A) a VNTR in the 5′ region of the insulin gene
B) glutamic acid decarboxylase 2 (GAD2)
C) HLA-B27
D) HLA-DQ
E) HLA-DR3

Question

Quizplus · Accepted Answer

The highest risk populations for the development of T1D are children born with the HLA DR3/4-DQ8 serotype allele which accounts for almost 50% of all children who develop antibodies against pancreatic islet cells and thus develop T1D by the age of 5.

Type 1 Diabetes Is Highly Associated with the Inheritance of Specific