Lysophospholipids (LPLs) exhibit biological properties resembling those of extracellular growth factors or signaling molecules. One of the most important LPLs is sphingosine-1-phosphate (S1P). Which of the following proteins is responsible for transmitting the signal-transduction processes of S1P? A) a G_i-type G-protein coupled receptor (GPCR) B) a nuclear receptor C) a receptor serine/threonine kinase D) a receptor tyrosine kinase E) a receptor tyrosine phosphatase

Question

Quizplus · Accepted Answer

The Answer is A
EXPLANATION: S1P functions via interaction with specific GPCRs. The first GPCR shown to bind S1P was called S1P₁. Currently, there are 5 characterized S1P receptors. The biological activities attributed to S1P interaction with any of the 5 identified receptors are broad. These activities include involvement in vascular system and central nervous system development, viability and reproduction, immune cell trafficking, cell adhesion, cell survival and mitogenesis, stress responses, tissue homeostasis, angiogenesis, and metabolic regulation.

Lysophospholipids (LPLs) Exhibit Biological Properties Resembling Those of Extracellular Growth