An oligosaccharide unit is transferred from dolichol pyrophosphate to an asparagine moiety of a protein in which of the following structures?
A) endosomes
B) lysosomes
C) mitochondria
D) nuclei
E) rough endoplasmic reticulum

Question

Quizplus · Accepted Answer

The transfer of an oligosaccharide unit from dolichol pyrophosphate to an asparagine residue of a protein occurs in the rough endoplasmic reticulum, a process known as N-linked glycosylation.  The formation of N-linked glycoproteins occurs in the endoplasmic reticulum (ER) through cotranslational addition of a preassembled carbohydrate core structure that is delivered via the carbohydrate-dolichol lipid intermediate. The preassembled carbohydrate core structure comprises 3 terminal residues of glucose attached to a branched cluster of 9 mannose residues that are in turn attached to 2 GlcNAc residues attached to dolichol pyrophosphate.

An Oligosaccharide Unit Is Transferred from Dolichol Pyrophosphate to an Asparagine