You are carrying out experiments to study DNA replication in a cell line derived from a breast cancer tumor. You discover that the replication process does not completely copy all of each chromosome. Examination of the process using electron microscopy indicates that replication ceases near to where the DNA strands are attached to the chromatin scaffold. Given these observations, which of the following activities is most likely to be defective in these cells?
A) DNA ligase
B) helicase
C) polymerase-α
D) single-stranded binding proteins
E) topoisomerase
Correct Answer:
Verified
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