Ribose-5-phosphate is activated for participation in nucleotide biosynthesis by conversion to which of the following derivatives?
A) ADP ribose
B) CDP ribose
C) GDP ribose
D) UDP ribose
E) 5-phosphoribosyl-1-pyrophosphate

Question

Quizplus · Accepted Answer

Ribose-5-phosphate is converted to 5-phosphoribosyl-1-pyrophosphate (PRPP), which is the activated form used in nucleotide biosynthesis. Both the salvage and de novo synthesis pathways of purine and pyrimidine biosynthesis lead to production of nucleoside-5′-phosphates through the utilization of an activated sugar intermediate. The activated sugar used is 5-phosphoribosyl-1-pyrophosphate (PRPP). PRPP is generated by the action of PRPP synthetase.

Ribose-5-Phosphate Is Activated for Participation in Nucleotide Biosynthesis by Conversion