High plasma levels of the lipoprotein particle identified as lipoprotein(a) (Lp[a]) have been shown to be a primary risk factor for coronary heart disease and stroke. Lp(a) is a unique lipoprotein assembled from low-density lipoprotein (LDL) and a single glycoprotein called apolipoprotein(a) (apo[a]). Apo(a) is associated with LDL via a disulfide linkage to which other apolipoprotein?
A) apoA-I
B) apoB-48
C) apoB-100
D) apoC-II
E) apoE

Question

Quizplus · Accepted Answer

Apolipoprotein(a) is associated with LDL via a disulfide linkage to apolipoprotein B-100 (apoB-100).  Lp(a) is composed of a common LDL nucleus linked to a molecule of apolipoprotein(a) (apo[a]) by disulfide bonds between a cysteine residue in a Kringle-IV (KIV) type 9 domain in apo(a) and a cysteine residue in apolipoprotein B-100 (apoB-100).

High Plasma Levels of the Lipoprotein Particle Identified as Lipoprotein(a)