You Are Studying Fatty Acid Synthesis in a Cell Line

You are studying fatty acid synthesis in a cell line isolated from a hepatic cancer. You discover that addition of glucose-6-phosphate does not lead to an increase in the rate of palmitic acid synthesis as is the situation in normal hepatic cells. Which of the following proteins is most likely to be altered in the hepatic cancer cells leading to the obtained results?

A) acetyl-CoA carboxylase
B) ATP-citrate lyase
C) ChREBP
D) fatty acid synthase
E) steroyl-CoA desaturase