A 5-year-old child was rushed to emergency room after accidentally consuming fluoroacetate, a known inhibitor of TCA cycle. Which of the following enzymes is inhibited by fluoroacetate?
A) aconitase
B) citrate synthase
C) isocitrate dehydrogenase
D) malate dehydrogenase
E) succinate dehydrogenase

Question

Quizplus · Accepted Answer

Fluoroacetate is converted to fluorocitrate in the body, which inhibits aconitase, an enzyme in the TCA cycle. Fluoroacetate is a structural analog of citrate and a strong competitive inhibitor of aconitase.

A 5-Year-Old Child Was Rushed to Emergency Room After Accidentally