When fatty acids with odd numbers of carbon atoms are oxidized in the β-oxidation pathway, the final product is 1 mole of acetyl-CoA and 1 mole of the 3-carbon molecule, propionyl-CoA. In order to use the propionyl carbons, the molecule is carboxylated, converted ultimately to succinyl-CoA, and fed into the TCA cycle. Which of the following represents the vitamin cofactor required in one of the steps of this conversion? A) cobalamin (B₁₂) B) pantothenic acid (B₅) C) pyridoxine (B₆) D) riboflavin (B₂) E) thiamine (B₁)

Question

Quizplus · Accepted Answer

Cobalamin (B12) is required for the conversion of methylmalonyl-CoA to succinyl-CoA, which is a step in the conversion of propionyl-CoA to succinyl-CoA.

When Fatty Acids with Odd Numbers of Carbon Atoms Are