What can proteomics reveal that genomics cannot?
A)The number of genes characteristic of a species.
B)The patterns of alternative splicing.
C)The set of proteins present within a cell or tissue type.
D)The levels of mRNAs present in a particular cell type.
E)The movement of transposable elements within the genome.

Question

Quizplus · Accepted Answer

Proteomics can reveal the set of proteins present within a cell or tissue type, which cannot be determined by genomics alone. Genomics only provides information about the genes present in the genome, but it cannot reveal which genes are turned on or off and which proteins are actually produced by the cell. Proteomics allows for the identification and characterization of a large number of functional proteins, which can provide insights about cell behavior and disease mechanisms.

Answer: B
 Proteomics can also reveal the patterns of alternative splicing. Alternative splicing is a complex process where different exons of a gene are combined to produce multiple protein isoforms, each with a unique function. Genomics can identify the genes that undergo alternative splicing, but it cannot predict the specific splicing patterns or the resulting protein isoforms. Proteomics can detect and quantify the protein isoforms produced by alternative splicing, which can be important for understanding cell differentiation and disease mechanisms.

What Can Proteomics Reveal That Genomics Cannot