Imagine that your goal is to isolate mouse mutants that stabilize microsatellite repeat sequences (i.e. ,lower the frequency at which their repeat number changes).Which of the following mutations would you predict to have this stabilizing effect?
A)a mutation that reduces the rate of transcription
B)a mutation that reduces the rate of translation
C)a mutation that increases the rate of DNA synthesis
D)a mutation that reduces the occurrence of homologous recombination
E)a mutation that inactivates reverse transcriptase and/or integrase

Question

Quizplus · Accepted Answer

Homologous recombination is a major mechanism for the instability of microsatellite repeat sequences. A mutation that reduces the occurrence of homologous recombination in mice would lower the frequency at which their repeat number changes and stabilize the microsatellite DNA.

Imagine That Your Goal Is to Isolate Mouse Mutants That