Imagine you've isolated a yeast mutant that contains a constitutively (constantly)active histone deacetylase.What phenotype do you predict for this mutant?
A)The mutant will grow rapidly.
B)The mutant will require galactose for growth.
C)The mutant will show low levels of gene expression.
D)The mutant will show high levels of gene expression.

Question

Quizplus · Accepted Answer

Histone deacetylase removes acetyl groups from histones, resulting in the compaction of chromatin and decreased accessibility of DNA to transcription factors. Constitutive activity of histone deacetylase would result in increased compaction of chromatin, leading to low levels of gene expression. Therefore, the best choice is C, the mutant will show low levels of gene expression.

Imagine You've Isolated a Yeast Mutant That Contains a Constitutively