REM sleep appears to be initiated when acetylcholine-secreting neurons become excited. This may occur when the activity of the serotonin-secreting neurons that normally inhibit these neurons is decreased.

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REM sleep is indeed initiated when acetylcholine-secreting neurons in the brainstem become excited, often due to a decrease in the activity of serotonin-secreting neurons that typically inhibit them. This process is part of the complex interplay of neurotransmitters that regulate sleep cycles, including the transition into REM sleep, which is characterized by rapid eye movements and vivid dreaming.

REM Sleep Appears to Be Initiated When Acetylcholine-Secreting Neurons Become