There is evidence that transexuality may be due to the androgen insensitivity syndrome.

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Androgen Insensitivity Syndrome (AIS) is a condition affecting sexual development before birth and during puberty. People with this condition are genetically male, with one X and one Y chromosome in each cell, but their bodies are unable to respond to male hormones (androgens) properly. This can lead to the development of mostly female external sex characteristics or signs of both male and female sexual development. Transexuality, however, refers to a person's identification with a gender different from their biological sex. The causes of transexuality are considered to be multifactorial, including biological, psychological, and social factors, rather than being directly caused by conditions like AIS.

There Is Evidence That Transexuality May Be Due to the Androgen