Olney's concept of excitotoxicity suggests that most neural death in ischemia is due to
A)excess cholinergic activity.
B)insufficient GABA activity.
C)insufficient glutamate activity.
D)excess glutamate activity.d

Question

Olney's concept of excitotoxicity suggests that most neural death in ischemia is due to 
A)excess cholinergic activity. 
B)insufficient GABA activity. 
C)insufficient glutamate activity. 
D)excess glutamate activity.d

Quizplus · Accepted Answer

Olney's concept of excitotoxicity suggests that excessive glutamate activity leads to an overload of calcium ions in neurons, causing them to become overstimulated and eventually leading to cell death. This is a major contributor to neural death in ischemia.

Olney's Concept of Excitotoxicity Suggests That Most Neural Death in Ischemia