A major drawback in using ECL logic circuits in conjunction with TTL and MOS circuits is its negative supply voltages and logic levels.

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ECL (Emitter-Coupled Logic) circuits typically require negative supply voltages, which can complicate interfacing with TTL (Transistor-Transistor Logic) and MOS (Metal-Oxide-Semiconductor) circuits that generally use positive supply voltages. This difference in voltage requirements can lead to additional complexity in mixed-technology designs.

A Major Drawback in Using ECL Logic Circuits in Conjunction