In areas where malaria frequency is low, the sickle cell homozygote has lower fitness than a homozygote with two copies of the normal $\beta$ -globin allele.

Question

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In areas with low malaria frequency, individuals with sickle cell disease (homozygous for the sickle cell allele) have lower fitness compared to individuals with two normal beta-globin alleles, due to the health problems associated with sickle cell disease and without the protective advantage against malaria.

In Areas Where Malaria Frequency Is Low, the Sickle Cell β\betaβ

In Areas Where Malaria Frequency Is Low, the Sickle Cell $\beta$