The activity of protein kinase A is affected by which of the following?
I. activated adenylate cyclase
II. levels of cAMP
III. phosphodiesterases
IV. cholera toxin

Question

Quizplus · Accepted Answer

Protein kinase A (PKA) activity is influenced by several factors: I. Activated adenylate cyclase increases levels of cyclic AMP (cAMP), which is a direct regulator of PKA. II. Levels of cAMP directly affect PKA activity since cAMP is a required molecule for PKA activation. III. Phosphodiesterases break down cAMP, thereby reducing PKA activity by lowering cAMP levels. IV. Cholera toxin can lead to increased cAMP levels by continuously activating adenylate cyclase, indirectly increasing PKA activity.

The Activity of Protein Kinase a Is Affected by Which