Why might a physician prescribe metoprolol rather than propranolol to treat high blood pressure? A) It works only in the central nervous system. B) It is more effective because it acts as an antagonist at all adrenergic receptors. C) It dilates blood vessels by antagonizing α₁-receptors. D) It has fewer side effects because it selectively antagonizes β₁-receptors.

Question

Quizplus · Accepted Answer

Metoprolol is a selective antagonist of β1-adrenergic receptors, which means it specifically targets the beta receptors in the heart and reduces their activity, resulting in a decrease in heart rate and blood pressure. In contrast, propranolol is a non-selective antagonist of both β1- and β2-adrenergic receptors, which can lead to unwanted side effects such as bronchoconstriction and worsening of asthma symptoms in some patients. Therefore, a physician may prescribe metoprolol over propranolol to treat high blood pressure in patients who have a history of respiratory issues or other medical conditions that may be exacerbated by non-selective beta blockade.

Why Might a Physician Prescribe Metoprolol Rather Than Propranolol to Treat