In a cholinergic neuron, if ACh remains in the cytoplasm but is not moving into synaptic vesicles in the nerve terminal for storage, which of the following scenarios might be true?
A) The choline transporter is blocked by the drug hemicholinium-3.
B) The vesicular transporter VAChT is blocked by the drug vesamicol.
C) The choline transporter is blocked by the drug pyridostigmine.
D) The vesicular transporter VAChT is blocked by the drug donepezil.

Question

Quizplus · Accepted Answer

The vesicular transporter VAChT is responsible for the storage of ACh into synaptic vesicles. If this transporter is blocked by the drug vesamicol, then ACh will not be able to enter the vesicles and will remain in the cytoplasm. The other answer choices relate to the inhibition of different transporters and enzymes involved in the synthesis and uptake of ACh and therefore do not fit the scenario described in the question.

In a Cholinergic Neuron, If ACh Remains in the Cytoplasm