Which statement correctly summarizes the translational studies using mGluR5 agonists to treat Fragile X syndrome?
A) Although mGluR5 agonists did not show promise in treating FXS in animal models, they did have efficacy in clinical trials.
B) Although mGluR5 agonists showed promise in treating FXS in animal models, they did not have efficacy in clinical trials.
C) Although the early mGlurR5 agonists did not improve FXS symptoms, a later drug, basimglurant, did.
D) mGluR5 agonists have been proven to reduce symptoms both in animal models and in people with FXS.

Question

Quizplus · Accepted Answer

mGluR5 agonists showed promise in preclinical studies using animal models of Fragile X syndrome (FXS), suggesting potential therapeutic benefits. However, this promise did not translate into efficacy in clinical trials involving humans, leading to disappointing outcomes for the use of mGluR5 agonists in treating FXS in clinical settings.

Which Statement Correctly Summarizes the Translational Studies Using MGluR5 Agonists