Cultured cells from xeroderma pigmentosum patients were unable to carry out
A) base-excision repair.
B) nucleotide-excision repair.
C) synthesis of melanin.
D) DNA synthesis.

Question

Quizplus · Accepted Answer

Xeroderma pigmentosum is a genetic disorder which affects the ability of the body to repair DNA damage caused by UV radiation. Specifically, it impairs nucleotide-excision repair, which is responsible for removing a wide range of DNA damage including UV-induced cyclobutane pyrimidine dimers (CPDs). Cells from patients with xeroderma pigmentosum are unable to carry out this repair, leading to an increased risk of skin cancer and other UV-induced DNA damage.

Cultured Cells from Xeroderma Pigmentosum Patients Were Unable to Carry