The nuclear localization signal (NLS) is not removed (cleaved off) after entry of the protein into the nucleus. In contrast, the targeting sequences of proteins destined for organelles such as the mitochondria are located at the N-terminus of the protein and are cleaved off once the proteins reach the lumen of the organelle. What are two likely reasons that the nuclear localization signal (NLS) is not cleaved off for nuclear proteins?

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The Answer of The nuclear localization signal (NLS) is not removed (cleaved off) after entry of the protein into the nucleus. In contrast, the targeting sequences of proteins destined for organelles such as the mitochondria are located at the N-terminus of the protein and are cleaved off once the proteins reach the lumen of the organelle. What are two likely reasons that the nuclear localization signal (NLS) is not cleaved off for nuclear proteins?

The Nuclear Localization Signal (NLS) Is Not Removed (Cleaved Off)