p21 inhibits cell cycle progression by binding to and inhibiting
A) cyclin-dependent kinases.
B) p53.
C) ATM.
D) Rb protein.

Question

Quizplus · Accepted Answer

p21 is a cyclin-dependent kinase (CDK) inhibitor that plays a crucial role in cell cycle regulation. By binding to and inhibiting cyclin-dependent kinases, p21 can halt the cell cycle, preventing cells from proliferating. This mechanism is particularly important in the context of DNA damage, where p21 activation helps to stop cell cycle progression to allow for DNA repair or to initiate apoptosis if the damage is irreparable.

P21 Inhibits Cell Cycle Progression by Binding to and Inhibiting