Which cyclin(s) is(are) required to pass the G₁ restriction point in animal cells? A) Cyclin A B) Cyclin A and Cyclin B C) Cyclin D D) Cyclin D and Cyclin E

Question

Quizplus · Accepted Answer

Cyclin D and Cyclin E are required to pass the G₁ restriction point in animal cells. Cyclin D activates CDK4/6, which then phosphorylates and activates the retinoblastoma protein (Rb). This allows for the release of E2F transcription factors and promotes the transcription of genes required for the G1/S transition. Cyclin E then activates CDK2, which promotes further progression through the cell cycle.

Which Cyclin(s) Is(are) Required to Pass the G1 Restriction Point

Which Cyclin(s) Is(are) Required to Pass the G₁ Restriction Point