Which serum enzyme is the most reliable marker of extrahepatic biliary obstruction?
A) Alanine aminotransferase
B) Aspartate aminotransferase
C) Creatine kinase
D) Amylase
E) Alkaline phosphatase

Question

Quizplus · Accepted Answer

Alkaline phosphatase is the most reliable marker of extrahepatic biliary obstruction. Its level rises significantly in the serum due to impaired bile flow caused by the obstruction. Other enzymes such as alanine aminotransferase, aspartate aminotransferase, creatine kinase, and amylase may also elevate in such cases, but none of them is as specific and sensitive as alkaline phosphatase.

Which Serum Enzyme Is the Most Reliable Marker of Extrahepatic