From the following possible methodological steps for producing evidence-based clinical practice guidelines, which combination includes widely accepted core principles?
1) They are carried out by members of the affected disciplinary groups.
2) A systematic review is identified or conducted prior to development of recommendations.
3) Only studies with a sample size greater than 100 are considered.
4) Recommendations are explicitly linked with supporting evidence.
5) Recommendations are set forth only for those issues for which there are two or more randomized controlled trials.
A) 1, 3, and 4
B) 2, 4, and 5
C) 1, 3, and 5
D) 1, 2, and 4

Question

Quizplus · Accepted Answer

A systematic review is essential to ensure recommendations are based on comprehensive evidence (2), recommendations should be explicitly linked to evidence (4), and involving members of the affected disciplinary groups ensures relevance and acceptance (1).

From the Following Possible Methodological Steps for Producing Evidence-Based Clinical