How does RNA polymerase II bind to the DNA?
A) It binds directly to the eukaryotic promoter sequence.
B) It binds directly to the TATA box.
C) It binds to transcription factors in the nucleus, and the complex then binds to the promoter.
D) Transcription factors first bind to the promoter, then recruit RNA polymerase II to that site.
E) Some transcription factors bind to the promoter, while others bind to RNA polymerase II, then the two groups of proteins bind to each other.

Question

Quizplus · Accepted Answer

Transcription factors first bind to the promoter region of DNA. These factors then serve as a platform or scaffold that recruits RNA polymerase II to the promoter, enabling it to begin transcription. This process ensures that RNA polymerase II is correctly positioned and oriented for efficient transcription initiation.

How Does RNA Polymerase II Bind to the DNA