When using leptin to control obesity, reduction in the activity of the _____ enzyme leads to a decrease in malonyl-CoA levels and oxidation of fatty acids by mitochondria.
A) acetyl-CoA carboxylase
B) D-xylulose reductase
C) pyruvate dehydrogenase
D) monoamine oxidase

Question

​ When using leptin to control obesity, reduction in the activity of the _____  enzyme leads to a decrease in malonyl-CoA levels and oxidation of fatty acids by mitochondria.
A) acetyl-CoA carboxylase
B) D-xylulose reductase
C) pyruvate dehydrogenase
D) monoamine oxidase

Quizplus · Accepted Answer

Acetyl-CoA carboxylase is the enzyme responsible for converting acetyl-CoA to malonyl-CoA, a critical step in fatty acid synthesis. Reduction in its activity would lead to decreased malonyl-CoA levels, promoting the oxidation of fatty acids by mitochondria, which is a desired effect in controlling obesity.

​ When Using Leptin to Control Obesity, Reduction in the Activity

When Using Leptin to Control Obesity, Reduction in the Activity