Neural tube defects cause an elevation in the alpha-fetoprotein (AFP) level in the mother's blood.

Name: Neural tube defects cause an elevation in the alpha-fetoprotein (AFP) level in the mother's blood.
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Neural tube defects, such as spina bifida and anencephaly, can lead to an increase in alpha-fetoprotein (AFP) levels in the amniotic fluid and maternal blood, as AFP leaks into the amniotic fluid and maternal circulation from the open neural tube defect.

Neural Tube Defects Cause an Elevation in the Alpha-Fetoprotein (AFP)