Thyroxine levels are regulated by a negative feedback mechanism involving the hypothalamus and adenohypophysis.

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Thyroxine levels are regulated by a negative feedback mechanism involving the hypothalamus and adenohypophysis. When thyroxine levels are low, the hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the adenohypophysis to secrete thyroid-stimulating hormone (TSH). TSH then stimulates the thyroid gland to produce and release more thyroxine. As thyroxine levels increase, they inhibit the release of TRH and TSH, creating a negative feedback loop to maintain homeostasis.

Thyroxine Levels Are Regulated by a Negative Feedback Mechanism Involving