In the following simplified diagram of the NF?B-dependent signaling pathway, indicate which boxes (A to C) correspond to the NF-?B, I?B, and IKK proteins, respectively. Your answer would be a three-letter string composed of letters A to C only, e.g. BCA.

Question

Quizplus · Accepted Answer

Various cell-surface receptors can activate NF?B in similar ways. I?B proteins bind tightly to NF?B and prevent their nuclear entry in the absence of the signal. In the presence of signal, IKK phosphorylates I?B to mark it for degradation. This frees NF?B to enter the nucleus and activate transcription of its target genes.

In the Following Simplified Diagram of the NF?B-Dependent Signaling Pathway