The following diagram depicts the topology of a multipass transmembrane protein in the endoplasmic reticulum (ER) membrane. Which set of helices act as stop-transfer signals in this protein?
A) 1, 2, 3
B) 4, 5, 6
C) 1, 3, 5
D) 2, 4, 6
E) 1, 6

Question

The following diagram depicts the topology of a multipass transmembrane protein in the endoplasmic reticulum (ER) membrane. Which set of helices act as stop-transfer signals in this protein? 
A) 1, 2, 3 
B) 4, 5, 6 
C) 1, 3, 5 
D) 2, 4, 6 
E) 1, 6

Quizplus · Accepted Answer

A stop-transfer signal directs its following segment in the protein to the cytosolic side of the membrane.

The Following Diagram Depicts the Topology of a Multipass Transmembrane