Indicate true (T) and false (F) statements below regarding DNA methylation in humans. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) DNA methylation makes repression of gene expression "leakier."
( ) DNA methylation at the promoter region is usually an indication of active transcription.
( ) CG islands are nonpermissive for RNA polymerase assembly.
( ) The dinucleotide 5?-GC-3? is much more common than 5?-CG-3? in the human genome.

Question

Indicate true (T) and false (F) statements below regarding DNA methylation in humans. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	DNA methylation makes repression of gene expression "leakier."
( )	DNA methylation at the promoter region is usually an indication of active transcription.
( )	CG islands are nonpermissive for RNA polymerase assembly.
( )	The dinucleotide 5?-GC-3? is much more common than 5?-CG-3? in the human genome.

Quizplus · Accepted Answer

DNA methylation helps to make repression of gene expression less leaky. RNA polymerase is often found bound to promoters within unmethylated CG islands, even when the associated gene is not being actively transcribed. Except in CG islands, 5?-CG-3? dinucleotides are rare in vertebrate genomes.

Indicate True (T) and False (F) Statements Below Regarding DNA